Product 05 of 14
Spore probiotic plus immune-supporting ingredients for isolated crews.
Isolation, workload and disrupted sleep are known to strain the immune system, and spaceflight adds changes in the body's microbial communities that have been linked to immune alteration.
The Immune Resilience Stack combines a spore probiotic with immune-supporting ingredients, designed for isolated crews facing stress. Studies are planned in isolated-crew settings such as Antarctic winter stations, which share the isolation, confinement and limited resupply of long missions.
It is a research programme. The aim is to define a stack that is safe, stable and measurable against immune and wellbeing markers.
The problem
In astronauts on 6 to 12 month ISS missions, gut, skin, nose and tongue microbes all shifted, with changes linked to skin rashes and immune alteration.
Source: published spaceflight studies and NASA planning figures; refers to work by other groups.
The science
Why this approach.
Long isolation, confinement, disrupted sleep and workload are associated with changes in immune function. In astronauts on 6 to 12 month ISS missions, the microbial communities of the gut, skin, nose and tongue all shifted, with changes linked to skin rashes and immune alteration.
The Immune Resilience Stack pairs a spore probiotic with immune-supporting ingredients. Antarctic winter stations provide a practical analog: crews are isolated and confined for months with limited resupply. Planned studies there would measure tolerance, wellbeing and immune markers, and show whether the stack is worth taking further.
In use
Across the length of a mission.
How this product is intended to fit into a crew's routine, from loading to return.
Components stored shelf-stable, with each ingredient tested for stability.
Taken daily, with timing designed to fit mission routines.
Maintained through demanding surface operations and stress periods.
Marker data reviewed to decide whether the formulation should change.
Design
Four decisions that shape it.
Spore probiotic core
Built on the same stable spore format as SpaceBiotic.
Supporting ingredients
Selected with evidence grading and kept to well-characterised, shelf-stable components.
Measurable outcomes
Study endpoints defined before testing begins.
Modular
Components can be adjusted as evidence develops.
Risks
What could go wrong, and what we do about it.
| Risk | How we address it |
|---|---|
| Ingredient interactions | Compatibility testing of the combined format before any study. |
| Placebo effects in small crews | Controlled study design and pre-registered endpoints. |
| Regulatory classification | Early regulatory strategy with partners; no claims beyond the evidence. |
Test plan
Ground, analog, orbit.
A staged programme: ground first, then analog crews, then flight.
Ground testing
Stability of every component and compatibility in the combined format.
Isolated-crew studies
Planned trials at Antarctic winter stations and similar sites.
Flight testing
Later stage, subject to analog results.
Partnerships
Polar research programmes and space-medicine groups.
Questions
FAQ.
Why Antarctica?
Winter-over crews are isolated, confined and resupply-limited, a useful analog for long missions.
Will it prevent illness?
We make no such claim. Nothing here is medical advice, and the product is in research.
Related
Works well with.
SpaceBiotic Spore Capsule
A room-temperature probiotic built on bacterial spores.
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Research programmeRead moreAll products on this site are under research and development. They are not approved or cleared by any regulator and are not available for sale. Nothing here is medical advice, and no product is intended to diagnose, treat, cure or prevent any disease. Descriptions of research refer to published studies by other groups and do not claim that our products have been proven in space. Immune Resilience Stack is a product under research and development and is not available for sale.
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